Extra-pituitary prolactin (PRL) and prolactin-like protein (PRL-L) in chickens and zebrafish.
Gen Comp Endocrinol
; 220: 143-53, 2015 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-25683198
ABSTRACT
It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior. However, there is increasing evidence showing that PRL and the newly identified 'prolactin-like protein (PRL-L)', a novel ligand of PRL receptor, are also expressed in a variety of extra-pituitary tissues, such as the brain, skin, ovary, and testes in non-mammalian vertebrates. In this brief review, we summarize the recent research progress on the structure, biological activities, and extra-pituitary expression of PRL and PRL-L in chickens (Gallus gallus) and zebrafish (Danio rerio) from our and other laboratories and briefly discuss their potential paracrine/autocrine roles in non-mammalian vertebrates, which may promote us to rethink the broad spectrum of PRL actions previously attributed to pituitary PRL only.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prolactina
/
Receptores de Prolactina
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Pez Cebra
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Proteínas Portadoras
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Pollos
Límite:
Animals
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Female
/
Humans
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Male
Idioma:
En
Revista:
Gen Comp Endocrinol
Año:
2015
Tipo del documento:
Article