SKI2162, an inhibitor of the TGF-ß type I receptor (ALK5), inhibits radiation-induced fibrosis in mice.
Oncotarget
; 6(6): 4171-9, 2015 Feb 28.
Article
en En
| MEDLINE
| ID: mdl-25686821
ABSTRACT
Here we demonstrated that SKI2162, a small-molecule inhibitor of the TGF-ß type I receptor (ALK5), prevented radiation-induced fibrosis (RIF) in mice. SKI2162 inhibited phosphorylation of Smad and induction of RIF-related genes in vitro. In RIF a mouse model, SKI2162 reduced late skin reactions and leg-contracture without jeopardizing the acute skin reaction. Irradiation of mouse tissue increased COL1A2 mRNA levels, and topical administration of SKI2162 significantly inhibited this effect. Thus, these findings support that SKI2162 has potential value as novel RIF-protective agent, and could be candidate for clinical trials.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos Experimentales por Radiación
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Protectores contra Radiación
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Proteínas Serina-Treonina Quinasas
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Receptores de Factores de Crecimiento Transformadores beta
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Prognostic_studies
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Oncotarget
Año:
2015
Tipo del documento:
Article