Cell-of-origin chromatin organization shapes the mutational landscape of cancer.

Polak, Paz; Karlic, Rosa; Koren, Amnon; Thurman, Robert; Sandstrom, Richard; Lawrence, Michael; Reynolds, Alex; Rynes, Eric; Vlahovicek, Kristian; Stamatoyannopoulos, John A; Sunyaev, Shamil R

Polak, Paz; Karlic, Rosa; Koren, Amnon; Thurman, Robert; Sandstrom, Richard; Lawrence, Michael; Reynolds, Alex; Rynes, Eric; Vlahovicek, Kristian; Stamatoyannopoulos, John A; Sunyaev, Shamil R.

Afiliación

Polak P; Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 02115.
Karlic R; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Koren A; Bioinformatics Group, Department of Molecular Biology, Division of Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.
Thurman R; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sandstrom R; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lawrence M; Departments of Genome Sciences and Medicine (Oncology), University of Washington, Seattle, WA 98195, USA.
Reynolds A; Departments of Genome Sciences and Medicine (Oncology), University of Washington, Seattle, WA 98195, USA.
Rynes E; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vlahovicek K; Departments of Genome Sciences and Medicine (Oncology), University of Washington, Seattle, WA 98195, USA.
Stamatoyannopoulos JA; Departments of Genome Sciences and Medicine (Oncology), University of Washington, Seattle, WA 98195, USA.
Sunyaev SR; Bioinformatics Group, Department of Molecular Biology, Division of Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia.

Nature ; 518(7539): 360-364, 2015 Feb 19.

Article en En | MEDLINE | ID: mdl-25693567

Asunto(s)

Cromatina/genética; Cromatina/metabolismo; Epigénesis Genética/genética; Mutación/genética; Neoplasias/genética; Neoplasias/patología; Línea Celular Tumoral; Cromatina/química; Momento de Replicación del ADN; Epigenómica; Genoma Humano/genética; Humanos; Melanocitos/metabolismo; Melanocitos/patología; Melanoma/genética; Melanoma/patología; Especificidad de Órganos/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatina / Epigénesis Genética / Mutación / Neoplasias Límite: Humans Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido

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