Scarless wound healing: chasing the holy grail.
Plast Reconstr Surg
; 135(3): 907-917, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25719706
ABSTRACT
Over 100 million patients acquire scars in the industrialized world each year, primarily as a result of elective operations. Although undefined, the global incidence of scarring is even larger, extending to significant numbers of burn and other trauma-related wounds. Scars have the potential to exert a profound psychological and physical impact on the individual. Beyond aesthetic considerations and potential disfigurement, scarring can result in restriction of movement and reduced quality of life. The formation of a scar following skin injury is a consequence of wound healing occurring through reparative rather than regenerative mechanisms. In this article, the authors review the basic stages of wound healing; differences between adult and fetal wound healing; various mechanical, genetic, and pharmacologic strategies to reduce scarring; and the biology of skin stem/progenitor cells that may hold the key to scarless regeneration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Piel
/
Fenómenos Fisiológicos de la Piel
/
Cicatrización de Heridas
/
Cicatriz
Aspecto:
Patient_preference
Límite:
Humans
Idioma:
En
Revista:
Plast Reconstr Surg
Año:
2015
Tipo del documento:
Article