Asymmetric aldol reaction of allenoates: regulation for the selective formation of isomeric allenyl or alkynyl aldol adduct.
Org Lett
; 17(6): 1573-6, 2015 Mar 20.
Article
en En
| MEDLINE
| ID: mdl-25736999
ABSTRACT
A highly stereoselective synthesis of 3-butynyl-threo-aldol adducts is achieved from the reaction of allyl allenoate with a chiral bromoborane in the presence of iPr2NEt, followed by addition of BF3·OEt2 as an additive to scavenge excess base and then aldehydes, whereas isomeric allenyl aldol adducts are formed in the absence of a Lewis acid additive from methyl allenoate.
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Colección:
01-internacional
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MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2015
Tipo del documento:
Article