H3 receptor renal expression in normal and diabetic rats.
Inflamm Res
; 64(5): 271-3, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25745947
ABSTRACT
INTRODUCTION:
To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R. MATERIALS ANDMETHODS:
Kidney specimens from 24 8-week-old male Wistar rats (12 non-diabetic and 12 diabetic animals) were processed for both immunohistochemical and immunofluorescence analyses. RESULTS ANDCONCLUSION:
H3R is expressed in the apical membrane by collecting duct cells in the kidney of rats and it is significantly increased in diabetic animals. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Histamínicos H3
/
Diabetes Mellitus Experimental
/
Riñón
Límite:
Animals
Idioma:
En
Revista:
Inflamm Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Italia