Pseudomonas aeruginosa injects type III effector ExoS into epithelial cells through the function of type IV pili.
FEBS Lett
; 589(8): 890-6, 2015 Apr 02.
Article
en En
| MEDLINE
| ID: mdl-25747138
ABSTRACT
Translocation of Pseudomonas aeruginosa through epithelial tissues can cause sepsis. Here, we examined whether P. aeruginosa penetrates epithelial cell layers using type IV pili (TFP). Deletion of TFP (pilA) did not affect association with Caco-2 cells, although it decreased penetration through, and disruption of, Caco-2 cell monolayers. We found that TFP are necessary for injection of the type III effector ExoS, which impairs defense against P. aeruginosa penetration, into host cells. Deletion of pilA attenuated oral infection in silkworms. We conclude that P. aeruginosa injects ExoS into cells through the function of TFP, enabling penetration of epithelial barriers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pseudomonas aeruginosa
/
Toxinas Bacterianas
/
ADP Ribosa Transferasas
/
Fimbrias Bacterianas
/
Células Epiteliales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón