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Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells.
Yuan, Chun-Xiu; Zhou, Zhi-Wei; Yang, Yin-Xue; He, Zhi-Xu; Zhang, Xueji; Wang, Dong; Yang, Tianxing; Pan, Si-Yuan; Chen, Xiao-Wu; Zhou, Shu-Feng.
Afiliación
  • Yuan CX; Department of Oncology, General Hospital, Ningxia Medical University, Yinchuan, People's Republic of China ; Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA.
  • Zhou ZW; Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA ; Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyan
  • Yang YX; Department of Colorectal Surgery, General Hospital, Ningxia Medical University, Yinchuan, People's Republic of China.
  • He ZX; Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, People's Republic of China.
  • Zhang X; Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, People's Republic of China.
  • Wang D; Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People's Republic of China.
  • Yang T; Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA.
  • Pan SY; Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
  • Chen XW; Department of General Surgery, The First People's Hospital of Shunde, Southern Medical University, Shunde, People's Republic of China.
  • Zhou SF; Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA.
Drug Des Devel Ther ; 9: 1293-318, 2015.
Article en En | MEDLINE | ID: mdl-25767376
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Neoplasias Gástricas / Benzamidas / Transducción de Señal / Apoptosis / Inhibidores de Proteínas Quinasas / Transición Epitelial-Mesenquimal / Puntos de Control del Ciclo Celular / Antineoplásicos Límite: Humans Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Nueva Zelanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Neoplasias Gástricas / Benzamidas / Transducción de Señal / Apoptosis / Inhibidores de Proteínas Quinasas / Transición Epitelial-Mesenquimal / Puntos de Control del Ciclo Celular / Antineoplásicos Límite: Humans Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Nueva Zelanda