Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.
Nat Struct Mol Biol
; 22(4): 342-344, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25775268
ABSTRACT
We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribosomas
/
ARN Bacteriano
/
ARN Ribosómico
/
Thermus thermophilus
Idioma:
En
Revista:
Nat Struct Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos