Practical molecular pathologic diagnosis of pilocytic astrocytomas.
Surg Pathol Clin
; 8(1): 63-71, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25783822
ABSTRACT
The pilocytic astrocytoma is predominantly a tumor of childhood and the most common type of circumscribed astrocytoma. The indolent nature of this tumor allows for prolonged survival for most patients, rendering the disease a rather "chronic" one, with potential long-term sequelae that are occasionally related to treatment. Two critical features of this tumor are its tendency to remain dormant, or involute even after subtotal resection, and the exceptional anaplastic transformation, sometimes following adjuvant therapy. The biological behavior of pilocytic astrocytoma can often be related to molecular alterations in the MAPK pathway.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Astrocitoma
/
Neoplasias Encefálicas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Surg Pathol Clin
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos