In situ evidence of pulmonary endothelial activation in patients with granulomatosis with polyangiitis and systemic sclerosis.
Lung
; 193(3): 355-9, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25787222
ABSTRACT
INTRODUCTION:
The aim of this study was to investigate the in situ pulmonary endothelial activation in lung lesions of granulomatosis with polyangiitis (GPA) and systemic sclerosis (SScl).METHODS:
We examined the endothelial expression of ICAM-1, VCAM-1, and E-selectin using immunohistochemistry on formalin-fixed, paraffin-embedded sections of lung lesions of GPA, interstitial lung disease associated with SScl and controls.RESULTS:
A significantly enhanced expression of ICAM-1 and E-selectin was observed in GPA and SScl pulmonary endothelium compared to controls. VCAM-1 was more pronouncedly expressed in GPA compared to SScl.CONCLUSION:
These observations are an evidence of in situ pulmonary vascular endothelial activation in lesions of GPA and SScl, adding information to the pathogenic knowledge of both diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esclerodermia Sistémica
/
Granulomatosis con Poliangitis
/
Enfermedades Pulmonares Intersticiales
/
Molécula 1 de Adhesión Intercelular
/
Molécula 1 de Adhesión Celular Vascular
/
Selectina E
/
Células Endoteliales
/
Pulmón
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Lung
Año:
2015
Tipo del documento:
Article