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Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.
Ting, Pamela Y; Damoiseaux, Robert; Titz, Björn; Bradley, Kenneth A; Graeber, Thomas G; Fernández-Vega, Virneliz; Bannister, Thomas D; Chase, Peter; Nair, Reji; Scampavia, Louis; Hodder, Peter; Spicer, Timothy P; Colicelli, John.
Afiliación
  • Ting PY; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
  • Damoiseaux R; California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America.
  • Titz B; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California
  • Bradley KA; Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, and California NanoSystems Institute, University of California Los Angeles, Los Angeles, California, United States of America.
  • Graeber TG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California at Los Angeles Metabolomics and Proteomics Center, California NanoSystems Institute and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California
  • Fernández-Vega V; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
  • Bannister TD; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America.
  • Chase P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
  • Nair R; The Scripps Research Institute-FL, Department of Chemistry, Translational Research Institute, Jupiter, Florida, United States of America.
  • Scampavia L; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
  • Hodder P; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
  • Spicer TP; The Scripps Research Institute-FL, Lead Identification, Translational Research Institute, Jupiter, Florida, United States of America.
  • Colicelli J; Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.
PLoS One ; 10(3): e0121833, 2015.
Article en En | MEDLINE | ID: mdl-25811598
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Proto-Oncogénicas c-abl / Péptidos y Proteínas de Señalización Intracelular / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Proto-Oncogénicas c-abl / Péptidos y Proteínas de Señalización Intracelular / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos