Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin.
Vitam Horm
; 98: 137-54, 2015.
Article
en En
| MEDLINE
| ID: mdl-25817868
ABSTRACT
Kinins, such as Bradykinin (BK), are peptide hormones of the kallikrein-kinin system. Apart from being a vasodilator, BK also increases urinary sodium excretion to reduce systemic blood pressure. It is becoming appreciated that BK modulates function of the epithelial Na(+) channel in the distal part of the renal nephron to affect tubular sodium reabsorption. In this chapter, we outline the molecular details, as well as discuss the physiological relevance of this regulation for the whole organism sodium homeostasis and setting chronic blood pressure.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sodio
/
Bradiquinina
/
Canales Epiteliales de Sodio
/
Reabsorción Renal
/
Nefronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vitam Horm
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA