[Age-dependent CYP1A2 gene polymorphism -163C>A in three ethnic groups of Bashkortostan Republic residents].
Adv Gerontol
; 27(3): 412-7, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25826985
ABSTRACT
On a sample of 1240 persons from Bashkortostan, including Russian, Bashkirs and Tatars, the analysis of allele and genotype frequencies distribution of CYP1A2 gene polymorphism -163C>A was performed by PCR-RFLP in view of belonging to a particular age cohort. In Russian and Bashkirs ethnic groups we observed age-dependent decrease of CYP1A2*C allele and CYP1A2*CI*C genotype frequencies (in Russian statistically significant for allele and genotype, the Bashkirs--only for allele) and a statistically significant increase of CYP1A2*A allele and CYP1A2*A/*A genotype frequencies. The set reduction in the frequency of the wild allele CYP1A2*C and increasing the frequency of the mutant allele CYP1A2*A with age may be due to greater survival of persons who are carriers of that allelic variants of CYP1A2 gene, providing a more efficient metabolism of xenobiotics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Envejecimiento
/
Citocromo P-450 CYP1A2
Límite:
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
País/Región como asunto:
Europa
Idioma:
Ru
Revista:
Adv Gerontol
Asunto de la revista:
GERIATRIA
Año:
2014
Tipo del documento:
Article