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Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Singh, Sheo B; Kaelin, David E; Wu, Jin; Miesel, Lynn; Tan, Christopher M; Black, Todd; Nargund, Ravi; Meinke, Peter T; Olsen, David B; Lagrutta, Armando; Lu, Jun; Patel, Sangita; Rickert, Keith W; Smith, Robert F; Soisson, Stephen; Sherer, Edward; Joyce, Leo A; Wei, Changqing; Peng, Xuanjia; Wang, Xiu; Fukuda, Hideyuki; Kishii, Ryuta; Takei, Masaya; Takano, Hisashi; Shibasaki, Mitsuhito; Yajima, Masanobu; Nishimura, Akinori; Shibata, Takeshi; Fukuda, Yasumichi.
Afiliación
  • Singh SB; Merck Research Laboratories, Kenilworth, NJ 07033, United States. Electronic address: sheo.singh.215@gmail.com.
  • Kaelin DE; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Wu J; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Miesel L; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Tan CM; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Black T; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Nargund R; Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Meinke PT; Merck Research Laboratories, Rahway 07065, United States.
  • Olsen DB; Merck Research Laboratories, West Point, PA 19486, United States.
  • Lagrutta A; Merck Research Laboratories, West Point, PA 19486, United States.
  • Lu J; Merck Research Laboratories, West Point, PA 19486, United States.
  • Patel S; Merck Research Laboratories, West Point, PA 19486, United States.
  • Rickert KW; Merck Research Laboratories, West Point, PA 19486, United States.
  • Smith RF; Merck Research Laboratories, West Point, PA 19486, United States.
  • Soisson S; Merck Research Laboratories, West Point, PA 19486, United States.
  • Sherer E; Merck Research Laboratories, Rahway 07065, United States.
  • Joyce LA; Merck Research Laboratories, Rahway 07065, United States.
  • Wei C; WuXi AppTec, Shanghai, People's Republic of China.
  • Peng X; WuXi AppTec, Shanghai, People's Republic of China.
  • Wang X; WuXi AppTec, Shanghai, People's Republic of China.
  • Fukuda H; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Kishii R; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Takei M; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Takano H; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Shibasaki M; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Yajima M; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Nishimura A; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Shibata T; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan.
  • Fukuda Y; Kyorin Pharmaceutical Co., Ltd, 2399-1, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: yasumichi.fukuda@gmail.com.
Bioorg Med Chem Lett ; 25(9): 1831-5, 2015 May 01.
Article en En | MEDLINE | ID: mdl-25851938
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN-Topoisomerasas de Tipo II / Ciclooctanos / Inhibidores de Topoisomerasa II / Bacterias Gramnegativas / Bacterias Grampositivas / Antibacterianos / Naftiridinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN-Topoisomerasas de Tipo II / Ciclooctanos / Inhibidores de Topoisomerasa II / Bacterias Gramnegativas / Bacterias Grampositivas / Antibacterianos / Naftiridinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido