Melatonin exerts protective effect on N2a cells under hypoxia conditions through Zip1/ERK pathway.
Neurosci Lett
; 595: 74-80, 2015 May 19.
Article
en En
| MEDLINE
| ID: mdl-25864781
ABSTRACT
Melatonin plays a neuroprotective role in different CNS injuries. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Here, we studied the effects of melatonin in hypoxia-induced N2a cells and our results demonstrated that melatonin not only reduced the level of ROS and MDA, induced the increase of SOD, but also increased the cell proliferation and inhibited cell apoptosis in hypoxia-induced N2a cells. Moreover, we identified that melatonin can activate the MAPK/ERK pathway via upregulating the expression of Zip1. Therefore, this study provides a new mechanism of melatonin and need our further study in detail.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Neuroprotectores
/
Proteína Quinasa 1 Activada por Mitógenos
/
Proteínas de Transporte de Catión
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Proteína Quinasa 3 Activada por Mitógenos
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Proteína Quinasa 7 Activada por Mitógenos
/
Melatonina
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
China