AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications.
Future Med Chem
; 7(4): 473-91, 2015.
Article
en En
| MEDLINE
| ID: mdl-25875874
ABSTRACT
The role of glutamate and its receptors in central nervous system biology and disease has long been of interest to scientists involved in both fundamental research and drug discovery, however the complex pharmacology and lack of highly selective compounds has severely hampered drug discovery efforts in this area. Recent advances in the identification and profiling of positive allosteric modulators of the AMPA receptor offer a potential way forward and the hope of a new treatment for schizophrenia. This article will review recent patent applications published in this area.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Antipsicóticos
/
Receptores AMPA
Límite:
Humans
Idioma:
En
Revista:
Future Med Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido