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Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.
Sarria, Ignacio; Pahlberg, Johan; Cao, Yan; Kolesnikov, Alexander V; Kefalov, Vladimir J; Sampath, Alapakkam P; Martemyanov, Kirill A.
Afiliación
  • Sarria I; Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.
  • Pahlberg J; Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, United States.
  • Cao Y; Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.
  • Kolesnikov AV; Department of Ophthalmology and Visual Sciences, Washington University in St.Louis, St. Louis, United States.
  • Kefalov VJ; Department of Ophthalmology and Visual Sciences, Washington University in St.Louis, St. Louis, United States.
  • Sampath AP; Jules Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, United States.
  • Martemyanov KA; Department of Neuroscience, The Scripps Research Institute, Jupiter, United States.
Elife ; 4: e06358, 2015 Apr 16.
Article en En | MEDLINE | ID: mdl-25879270
In the retina, synaptic transmission between photoreceptors and downstream ON-bipolar neurons (ON-BCs) is mediated by a GPCR pathway, which plays an essential role in vision. However, the mechanisms that control signal transmission at this synapse and its relevance to behavior remain poorly understood. In this study we used a genetic system to titrate the rate of GPCR signaling in ON-BC dendrites by varying the concentration of key RGS proteins and measuring the impact on transmission of signal between photoreceptors and ON-BC neurons using electroretinography and single cell recordings. We found that sensitivity, onset timing, and the maximal amplitude of light-evoked responses in rod- and cone-driven ON-BCs are determined by different RGS concentrations. We further show that changes in RGS concentration differentially impact visually guided-behavior mediated by rod and cone ON pathways. These findings illustrate that neuronal circuit properties can be modulated by adjusting parameters of GPCR-based neurotransmission at individual synapses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Células Fotorreceptoras Retinianas Bastones / Células Fotorreceptoras Retinianas Conos / Transmisión Sináptica / Células Bipolares de la Retina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Elife Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sinapsis / Células Fotorreceptoras Retinianas Bastones / Células Fotorreceptoras Retinianas Conos / Transmisión Sináptica / Células Bipolares de la Retina Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Elife Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido