[Synthesis, isomery, and hypotensive activity of thiethane-containing ylidenehydrazides of uracilylacetic acid].
Bioorg Khim
; 40(3): 327-34, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25898740
ABSTRACT
Using reaction of hydrazide 2-[6-methyl-1-(thiethane3-yl)uracil-3-yl]acetic acid with arylaldehydes and acetophenone derivatives were obtained acylhydrazones, which exist in DMSO solution as a mixture of two stereoisomers of a E(C=N)-isomer for due to hindered internal rotation around the hydrazide bond. It was revealed that the synthesized compounds exhibit antihypertensive activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Uracilo
/
Hipertensión
/
Antihipertensivos
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Bioorg Khim
Año:
2014
Tipo del documento:
Article