Pharmacogenomic assessment of Mexican and Peruvian populations.
Pharmacogenomics
; 16(5): 441-8, 2015.
Article
en En
| MEDLINE
| ID: mdl-25916516
ABSTRACT
BACKGROUND:
Clinically relevant polymorphisms often demonstrate population-specific allele frequencies. Central and South America remain largely uncategorized in the context of pharmacogenomics. MATERIALS &METHODS:
We assessed 15 polymorphisms from 12 genes (ABCB1 3435C>T, ABCG2 Q141K, CYP1B1*3, CYP2C19*2, CYP3A4*1B, CYP3A5*3C, ERCC1 N118N, ERCC2 K751Q, GSTP1 I105V, TPMT 238G>C, TPMT 460G>A, TPMT 719A>G, TYMS TSER, UGT1A1*28 and UGT1A1 -3156G>A) in 81 Peruvian and 95 Mexican individuals.RESULTS:
Six polymorphism frequencies differed significantly between the two populations ABCB1 3435C>T, CYP1B1*3, GSTP1 I105V, TPMT 460G>A, UGT1A1*28 and UGT1A1 -3156G>A. The pattern of observed allele frequencies for all polymorphisms could not be accurately estimated from any single previously studied population.CONCLUSION:
This highlights the need to expand the scope of geographic data for use in pharmacogenomics studies.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Farmacogenética
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Mexico
/
Peru
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá