Histamine reduces boron neutron capture therapy-induced mucositis in an oral precancer model.
Oral Dis
; 21(6): 770-7, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-25926141
ABSTRACT
OBJECTIVES:
Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor development from field-cancerized tissue in the hamster cheek pouch model. However, BNCT-induced mucositis in field-cancerized tissue was dose limiting. In a clinical scenario, oral mucositis affects patients' treatment and quality of life. Our aim was to evaluate different radioprotectors, seeking to reduce the incidence of BNCT-induced severe mucositis in field-cancerized tissue. MATERIALS ANDMETHODS:
Cancerized pouches treated with BNCT mediated by boronophenylalanine at 5 Gy were treated as follows control saline solution; Hishigh histamine 5 mg kg(-1) ; Hislow histamine 1 mg kg(-1) ; and JNJ7777120 10 mg kg(-1).RESULTS:
Hislow reduced the incidence of severe mucositis in field-cancerized tissue to 17% vs CONTROL 55%; Hishigh 67%; JNJ7777120 57%. Hislow was non-toxic and did not compromise the long-term therapeutic effect of BNCT or alter gross boron concentration.CONCLUSION:
Histamine reduces BNCT-induced mucositis in experimental oral precancer without jeopardizing therapeutic efficacy. The fact that both histamine and boronophenylalanine are approved for use in humans bridges the gap between experimental work and potential clinical application to reduce BNCT-induced radiotoxicity in patients with head and neck cancer.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lesiones Precancerosas
/
Traumatismos Experimentales por Radiación
/
Protectores contra Radiación
/
Estomatitis
/
Neoplasias de la Boca
/
Histamina
/
Terapia por Captura de Neutrón de Boro
Tipo de estudio:
Etiology_studies
Aspecto:
Patient_preference
Límite:
Animals
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Argentina