[Activity of the enzymes which take part in aldehyde catabolism in the mitochondria of skeletal muscle in rats of different ages and its modulation during stress].

The purpose of this study was a comparative investigation of activity of enzymes, which take part in utilization of endogenous aldehydes in mitochondrial fraction of femoral muscle in intact and immobilized rats of different age. It has been shown that 12-months-old (adult) rats have high basal levels of NAD-aldehyde dehydrogenase, NADH-aldehyde reductase and glutathione transferase activity in mitochondrial fraction of femoral muscle. An increased of NAD-aldehyde dehydrogenase activity emerges during immobilization stress in adult rats. These changes contribute to enhancing the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-months-old rats during stress. Immobilization of old and pubertal rats, is accompanied by a certain arise in metabolic preconditions, leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and an increase in manifestation of sarcopenia.