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An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System.
Tseng, Ting-Chen; Tao, Lei; Hsieh, Fu-Yu; Wei, Yen; Chiu, Ing-Ming; Hsu, Shan-hui.
Afiliación
  • Tseng TC; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Tao L; The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
  • Hsieh FY; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
  • Wei Y; The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
  • Chiu IM; Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, 35053, Taiwan, R.O.C.
  • Hsu SH; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
Adv Mater ; 27(23): 3518-24, 2015 Jun 17.
Article en En | MEDLINE | ID: mdl-25953204
ABSTRACT
An injectable, self-healing hydrogel (≈1.5 kPa) is developed for healing nerve-system deficits. Neurosphere-like progenitors proliferate in the hydrogel and differentiate into neuron-like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of the hydrogel and significantly rescued by injection of the neurosphere-laden hydrogel. The self-healing hydrogel may thus potentially repair the central nervous system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Sistema Nervioso Central / Hidrogel de Polietilenoglicol-Dimetacrilato / Fenómenos Mecánicos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2015 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Sistema Nervioso Central / Hidrogel de Polietilenoglicol-Dimetacrilato / Fenómenos Mecánicos Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2015 Tipo del documento: Article