[Strength and specificity of the CMBA screening platform for bioactive molecules discovery]. / Force et spécificité du criblage pour des molécules bioactives au CMBA-Grenoble - Une plate-forme dédiée à la découverte et à l'analyse de molécules bioactives et candidats médicaments.
Med Sci (Paris)
; 31(4): 423-31, 2015 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-25958761
ABSTRACT
Used as powerful chemical probes in Life science fundamental research, the application potential of new bioactive molecular entities includes but extends beyond their development as therapeutic drugs in pharmacology. In this review, we wish to point out the methodology of chemical libraries screening on living cells or purified proteins at the CMBA academic platform of Grenoble Alpes University, and strategies employed to further characterize the selected bioactive molecules by phenotypic profiling on human cells. Multiple application fields are concerned by the screening activity developed at CMBA with bioactive molecules previously selected for their potential as tools for fundamental research purpose, therapeutic candidates to treat cancer or infection, or promising compounds for production of bioenergy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Evaluación Preclínica de Medicamentos
/
Bibliotecas de Moléculas Pequeñas
/
Descubrimiento de Drogas
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
Fr
Revista:
Med Sci (Paris)
Asunto de la revista:
MEDICINA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia