Gut Colonization of Healthy Children and Their Mothers With Pathogenic Ciprofloxacin-Resistant Escherichia coli.
J Infect Dis
; 212(12): 1862-8, 2015 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-25969564
ABSTRACT
BACKGROUND:
The reservoir of pathogenic ciprofloxacin-resistant Escherichia coli remains unknown.METHODS:
We conducted a prospective cohort study of 80 healthy twins and their mothers to determine the frequency of excretion of ciprofloxacin-resistant, potentially pathogenic E. coli. Stool specimens were cultured selectively for ciprofloxacin-resistant gram-negative bacteria. Isolates were categorized on the basis of additional resistance and virulence profiles. We also prospectively collected clinical metadata.RESULTS:
Fifteen children (19%) and 8 mothers (20%) excreted ciprofloxacin-resistant E. coli at least once. Overall, 33% of 40 families had at least 1 member whose stool specimen yielded ciprofloxacin-resistant E. coli on culture. Fifty-seven submitted stool specimens (2.8%) contained such organisms; clones ST131-H30 and ST405 accounted for 52 and 5 of the positive specimens, respectively. Length of hospital stay after birth (P = .002) and maternal colonization (P = .0001) were associated with subsequent childhood carriage of ciprofloxacin-resistant E. coli; antibiotic use, acid suppression, sex, mode of delivery, and maternal perinatal antibiotic use were not. Ciprofloxacin-resistant E. coli were usually resistant to additional antibiotic classes, and all had virulence genotypes typical of extraintestinal pathogenic E. coli.CONCLUSIONS:
Healthy children and their mothers commonly harbor ciprofloxacin-resistant E. coli with pathogenic potential.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Portador Sano
/
Ciprofloxacina
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Farmacorresistencia Bacteriana
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Tracto Gastrointestinal
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Escherichia coli
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Infecciones por Escherichia coli
/
Antibacterianos
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Infect Dis
Año:
2015
Tipo del documento:
Article