Short-term risk of cancer among women with previous gestational diabetes: a population-based study.
Diabet Med
; 33(1): 39-46, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-25970380
ABSTRACT
AIMS:
To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum.METHODS:
This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 12, to pregnant women without diabetes (N = 99 365).RESULTS:
Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% CI 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% CI 0.75, 0.98) compared with matched control subjects.CONCLUSIONS:
This large population-based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Embarazo en Diabéticas
/
Neoplasias de la Tiroides
/
Diabetes Gestacional
/
Premenopausia
/
Periodo Posparto
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Diabet Med
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Canadá