Structural Differences between Wild-Type and Double Mutant EGFR Modulated by Third-Generation Kinase Inhibitors.

Lowder, Melissa A; Doerner, Amy E; Schepartz, Alanna

Lowder, Melissa A; Doerner, Amy E; Schepartz, Alanna.

Afiliación

Lowder MA; Departments of Chemistry, Molecular Biophysics and Biochemistry, and §Molecular, Cellular, and Developmental Biology, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.
Doerner AE; Departments of Chemistry, Molecular Biophysics and Biochemistry, and §Molecular, Cellular, and Developmental Biology, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.
Schepartz A; Departments of Chemistry, Molecular Biophysics and Biochemistry, and §Molecular, Cellular, and Developmental Biology, Yale University, 225 Prospect Street, New Haven, Connecticut 06511, United States.

J Am Chem Soc ; 137(20): 6456-9, 2015 May 27.

Article en En | MEDLINE | ID: mdl-25973741

Asunto(s)

Receptores ErbB/antagonistas & inhibidores; Receptores ErbB/química; Proteínas Mutantes/antagonistas & inhibidores; Proteínas Mutantes/química; Mutación; Inhibidores de Proteínas Quinasas/farmacología; Animales; Células CHO; Cricetulus; Receptores ErbB/genética; Modelos Moleculares; Estructura Molecular; Proteínas Mutantes/genética; Inhibidores de Proteínas Quinasas/química; Relación Estructura-Actividad

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteínas Quinasas / Proteínas Mutantes / Receptores ErbB / Mutación Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Am Chem Soc Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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