External validation of the prognostic index in acute paraquat poisoning.
Hum Exp Toxicol
; 35(4): 366-70, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-25977258
ABSTRACT
OBJECTIVE:
Some studies have evaluated the prognostic indicators associated with acute paraquat (PQ) poisoning. In this study, we externally validated the Yamaguchi index, which showed a good prognostic relevance in predicting the outcome of PQ poisoning.METHODS:
A retrospective analysis of 297 patients was performed. The Yamaguchi index was calculated using the following equation Eq1 = (K(+) × HCO3(-))/(Creatinine × 0.088)(mEq/L) against time from PQ ingestion (T). The patients were divided into three groups group A Eq1 > 1500 - 399 × log T, group B 930 - 399 × log T < Eq1 ≤ 1500 - 399 × log T, and group C Eq1 ≤ 930 - 399 × log T).RESULTS:
The overall mortality rate was 65.3% (194 of 297). The mortality rates of the three groups stratified by the Yamaguchi index were 7.1% (2 of 28), 22.4% (15 of 67), and 87.6% (177 of 202). The area under the receiver-operating characteristic curve for predicting mortality from the external validation of the Yamaguchi index was 0.842 (95% confidence interval 0.795-0.882).CONCLUSION:
The Yamaguchi index is a reliable prognostic factor and could be helpful in predicting mortality due to PQ poisoning.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Paraquat
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Hum Exp Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2016
Tipo del documento:
Article