Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum.
Biol Open
; 4(7): 865-72, 2015 May 15.
Article
en En
| MEDLINE
| ID: mdl-25979710
ABSTRACT
The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of ß-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of ß-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of ß-Catenin was shown to occur towards the source of a localized extracellular cue.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Biol Open
Año:
2015
Tipo del documento:
Article
País de afiliación:
India