Glycan variation and evolution in the eukaryotes.
Trends Biochem Sci
; 40(7): 351-9, 2015 Jul.
Article
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| MEDLINE
| ID: mdl-26002999
ABSTRACT
In this review, we document the evolution of common glycan structures in the eukaryotes, and illustrate the considerable variety of oligosaccharides existing in these organisms. We focus on the families of N- and O-glycans, glycosphingolipids, glycosaminoglycans, glycosylphosphatidylinositol (GPI) anchors, sialic acids (Sias), and cytoplasmic and nuclear glycans. We also outline similar and divergent aspects of the glycans during evolution within the groups, which include inter- and intraspecies differences, molecular mimicry, viral glycosylation adaptations, glycosyltransferase specificity relating to function, and the natural dynamism powering these events. Finally, we present an overview of the patterns of glycosylation found within the groups comprising the Eukaryota, namely the Deuterostomia, Fungi, Viridiplantae, Nematoda, and Arthropoda.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Procesamiento Proteico-Postraduccional
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2015
Tipo del documento:
Article