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High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Harris, Philip A; Duraiswami, Chaya; Fisher, Donald T; Fornwald, James; Hoffman, Sandra J; Hofmann, Glenn; Jiang, Ming; Lehr, Ruth; McCormick, Patricia M; Nickels, Leng; Schwartz, Benjamin; Wu, Zining; Zhang, Guofeng; Marquis, Robert W; Bertin, John; Gough, Peter J.
Afiliación
  • Harris PA; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA. Electronic address: philip.a.harris@gsk.com.
  • Duraiswami C; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Fisher DT; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Fornwald J; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Hoffman SJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Hofmann G; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Jiang M; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Lehr R; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • McCormick PM; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Nickels L; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Schwartz B; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Wu Z; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Zhang G; Platform Technology & Science, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Marquis RW; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Bertin J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
  • Gough PJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville Road, Collegeville, PA 19426, USA.
Bioorg Med Chem Lett ; 25(14): 2739-43, 2015 Jul 15.
Article en En | MEDLINE | ID: mdl-26022841
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Proteínas Adaptadoras Transductoras de Señales / Proteínas Reguladoras de la Apoptosis / Inflamasomas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenosina Trifosfato / Proteínas Adaptadoras Transductoras de Señales / Proteínas Reguladoras de la Apoptosis / Inflamasomas Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido