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Plasmodium falciparum genetic crosses in a humanized mouse model.
Vaughan, Ashley M; Pinapati, Richard S; Cheeseman, Ian H; Camargo, Nelly; Fishbaugher, Matthew; Checkley, Lisa A; Nair, Shalini; Hutyra, Carolyn A; Nosten, François H; Anderson, Timothy J C; Ferdig, Michael T; Kappe, Stefan H I.
Afiliación
  • Vaughan AM; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington, USA.
  • Pinapati RS; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
  • Cheeseman IH; Texas Biomedical Research Institute, San Antonio, Texas, USA.
  • Camargo N; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington, USA.
  • Fishbaugher M; Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington, USA.
  • Checkley LA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
  • Nair S; Texas Biomedical Research Institute, San Antonio, Texas, USA.
  • Hutyra CA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
  • Nosten FH; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot, Thailand.
  • Anderson TJ; Texas Biomedical Research Institute, San Antonio, Texas, USA.
  • Ferdig MT; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
  • Kappe SH; 1] Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington, USA. [2] Department of Global Health, University of Washington, Seattle, Washington, USA.
Nat Methods ; 12(7): 631-3, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26030447
ABSTRACT
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Cruzamientos Genéticos Límite: Animals / Humans Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium falciparum / Cruzamientos Genéticos Límite: Animals / Humans Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos