[Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis].
Zhejiang Da Xue Xue Bao Yi Xue Ban
; 44(2): 211-6, 2015 03.
Article
en Zh
| MEDLINE
| ID: mdl-26038142
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-ß, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transición Epitelial-Mesenquimal
/
Metástasis de la Neoplasia
/
Recurrencia Local de Neoplasia
Límite:
Humans
Idioma:
Zh
Revista:
Zhejiang Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2015
Tipo del documento:
Article