Acute pentobarbital treatment impairs spatial learning and memory and hippocampal long-term potentiation in rats.
Physiol Behav
; 149: 169-73, 2015 Oct 01.
Article
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| MEDLINE
| ID: mdl-26056078
ABSTRACT
Reports of the effects of pentobarbital on learning and memory are contradictory. Some studies have not shown any interference with learning and memory, whereas others have shown that pentobarbital impairs memory and that these impairments can last for long periods. However, it is unclear whether acute local microinjections of pentobarbital affect learning and memory, and if so, the potential mechanisms are also unclear. Here, we reported that the intra-hippocampal infusion of pentobarbital (8.0mM, 1µl per side) significantly impaired hippocampus-dependent spatial learning and memory retrieval. Moreover, in vitro electrophysiological recordings revealed that these behavioral changes were accompanied by impaired hippocampal CA1 long-term potentiation (LTP) and suppressed neuronal excitability as reflected by a decrease in the number of action potentials (APs). These results suggest that acute pentobarbital application causes spatial learning and memory deficits that might be attributable to the suppression of synaptic plasticity and neuronal excitability.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pentobarbital
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Potenciación a Largo Plazo
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Hipocampo
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Hipnóticos y Sedantes
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Discapacidades para el Aprendizaje
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Trastornos de la Memoria
Límite:
Animals
Idioma:
En
Revista:
Physiol Behav
Año:
2015
Tipo del documento:
Article