Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase.

Szymanski, Michal R; Kuznetsov, Vladmir B; Shumate, Christie; Meng, Qingchao; Lee, Young-Sam; Patel, Gayatri; Patel, Smita; Yin, Y Whitney

Szymanski, Michal R; Kuznetsov, Vladmir B; Shumate, Christie; Meng, Qingchao; Lee, Young-Sam; Patel, Gayatri; Patel, Smita; Yin, Y Whitney.

Afiliación

Szymanski MR; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX, USA.
Kuznetsov VB; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX, USA.
Shumate C; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX, USA.
Meng Q; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Lee YS; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Patel G; Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Patel S; Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Yin YW; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX, USA ywyin@utmb.edu.

EMBO J ; 34(14): 1959-70, 2015 Jul 14.

Article en En | MEDLINE | ID: mdl-26056153

Asunto(s)

ADN Polimerasa Dirigida por ADN/química; ADN Polimerasa Dirigida por ADN/metabolismo; Zalcitabina/toxicidad; Secuencia de Aminoácidos; Secuencia de Bases; Sitios de Unión; Dominio Catalítico; Cristalografía por Rayos X; ADN Polimerasa gamma; ADN Mitocondrial/metabolismo; ADN Polimerasa Dirigida por ADN/genética; Humanos; Modelos Moleculares; Datos de Secuencia Molecular; Mutación; Conformación Proteica; Inhibidores de la Transcriptasa Inversa/química; Inhibidores de la Transcriptasa Inversa/metabolismo; Inhibidores de la Transcriptasa Inversa/toxicidad; Zalcitabina/química; Zalcitabina/metabolismo

Palabras clave

DNA replication; drug toxicity; human DNA polymerase gamma; mitochondrial toxicity; nucleoside reverse transcriptase inhibitors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zalcitabina / ADN Polimerasa Dirigida por ADN Límite: Humans Idioma: En Revista: EMBO J Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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