Cloning, expression, purification, crystallization and preliminary X-ray diffraction studies of NAD synthetase from methicillin-resistant Staphylococcus aureus.
Acta Crystallogr F Struct Biol Commun
; 71(Pt 6): 763-9, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-26057809
ABSTRACT
Staphylococcus aureus is an important human and animal pathogen that causes a wide range of infections. The prevalence of multidrug-resistant S. aureus strains in both hospital and community settings makes it imperative to characterize new drug targets to combat S. aureus infections. In this context, enzymes involved in NAD metabolism and synthesis are significant drug targets as NAD is a central player in several cellular processes. NAD synthetase catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide, making it a crucial intermediate enzyme linked to the biosynthesis of several amino acids, purine and pyrimidine nucleotides, coenzymes and antibiotics.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Amida Sintasas
/
Staphylococcus aureus Resistente a Meticilina
/
NAD
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Acta Crystallogr F Struct Biol Commun
Año:
2015
Tipo del documento:
Article
País de afiliación:
India