Growth hormone insensitivity: diagnostic and therapeutic approaches.
J Endocrinol Invest
; 39(1): 19-28, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26062520
ABSTRACT
INTRODUCTION:
Growth hormone resistance defines several genetic (primary) and acquired (secondary) pathologies that result in completely or partially interrupted activity of growth hormone. An archetypal disease of this group is the Laron-type dwarfism caused by mutations in growth hormone receptors. The diagnosis is based on high basal levels of growth hormone, low insulin like growth factor-I (IGF-1) level, unresponsiveness to IGF generation test and genetic testing. Recombinant IGF-1 preparations are used in the treatmentCONCLUSION:
In this article, clinical characteristics, diagnosis and therapeutic approaches of the genetic and other diseases leading to growth hormone insensitivity are reviewed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a Medicamentos
/
Hormona del Crecimiento
/
Síndrome de Laron
/
Trastornos del Crecimiento
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Endocrinol Invest
Año:
2016
Tipo del documento:
Article
País de afiliación:
Turquía