[Depression comorbid to ischemic heart disease: a psychometric and molecular-genetic study].
Zh Nevrol Psikhiatr Im S S Korsakova
; 115(2): 42-47, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26081323
ABSTRACT
OBJECTIVE:
To compare psychometric and molecular-genetic characteristics of depression caused by ischemic heart disease (IHD) and depression in patients with IHD caused by other psychogenic factors. MATERIAL ANDMETHODS:
One hundred and thirty-five patients with depression comorbid to ischemic heart disease (IHD) were examined. Depression was associated with IHD in 71 patients (group 1). In 64 patients, depression was caused by other psychogenic factors (group 2). The HAMD-21 scale was used to measure depressive symptoms. RESULTS ANDCONCLUSION:
The comparative analysis of the core symptoms of depression demonstrated that group 1 had a peculiar psychometric profile with marked apathy, which was not accompanied by marked hypothymia, guilt feelings or anxiety, compared to group 2. The molecular-genetic correlate of this profile was found. It included a combination of an allele S (5-HTTLPR) of the serotonin transporter gene, an allele G (A-1438G) of the serotonin receptor type 2A gene and the genotype ValVal (Val66Met) of the brain-derived neurotrophic factor gene.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
ADN
/
Isquemia Miocárdica
/
Factor Neurotrófico Derivado del Encéfalo
/
Depresión
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
/
Estudios de Asociación Genética
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Asia
/
Europa
Idioma:
Ru
Revista:
Zh Nevrol Psikhiatr Im S S Korsakova
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2015
Tipo del documento:
Article