Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis.
Mult Scler
; 22(2): 245-9, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26084349
ABSTRACT
BACKGROUND:
The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown.OBJECTIVE:
To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis.METHODS:
CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing-remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls.RESULTS:
CSF amounts of 78 kDa HLA-G dimers were more frequent in RRMS than in inflammatory (p<0.01) and non-inflammatory controls (p<0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS (p<0.00001).CONCLUSION:
Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Encéfalo
/
Esclerosis Múltiple Recurrente-Remitente
/
Antígenos HLA-G
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Mult Scler
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Italia