[Endothelium Aging and Oxidative Stress].
Sheng Li Ke Xue Jin Zhan
; 46(1): 23-7, 2015 Feb.
Article
en Zh
| MEDLINE
| ID: mdl-26103722
ABSTRACT
In the endothelium, ROS mainly derive from mitochondria, endothelial nitric oxide synthases and NADPH oxidases 4. Excessive ROS are a major cause of oxidative stress, the primary stimulus of vascular dysfunction and oxidative stress-related diseases. However, cellular evolution has made possible the development of adaptive antioxidant systems that scavenge excessive ROS, such as Nrf2/Keapl-ARE, PPAR-y, SIRT and FOXO, etc. Among them, the Nrf2/Keapl-ARE signaling pathway is perhaps the most prominent. What is more, there are the "crosstalk" among these antioxidant stress-related signaling pathways aim to alleviate oxidative stress injurys and promote cells survival. The understanding of the relationship between endothelial aging and oxidative stress may serve as a therapeutic clues in the treatment of oxidative stress-related diseases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Senescencia Celular
/
Estrés Oxidativo
/
Óxido Nítrico Sintasa de Tipo III
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Sheng Li Ke Xue Jin Zhan
Año:
2015
Tipo del documento:
Article