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Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.
Sedic, Maja; Skibinski, Adam; Brown, Nelson; Gallardo, Mercedes; Mulligan, Peter; Martinez, Paula; Keller, Patricia J; Glover, Eugene; Richardson, Andrea L; Cowan, Janet; Toland, Amanda E; Ravichandran, Krithika; Riethman, Harold; Naber, Stephen P; Näär, Anders M; Blasco, Maria A; Hinds, Philip W; Kuperwasser, Charlotte.
Afiliación
  • Sedic M; 1] Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA [2] Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachu
  • Skibinski A; 1] Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA [2] Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachu
  • Brown N; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.
  • Gallardo M; Telomeres and Telomerase Group, Spanish National Cancer Centre, Madrid E-28029, Spain.
  • Mulligan P; Department of Cell Biology, Harvard Medical School and Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
  • Martinez P; Telomeres and Telomerase Group, Spanish National Cancer Centre, Madrid E-28029, Spain.
  • Keller PJ; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.
  • Glover E; 1] Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA [2] Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachu
  • Richardson AL; Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.
  • Cowan J; Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.
  • Toland AE; Department of Molecular Virology, Immunology, and Medical Genetics, Department of Internal Medicine's Division of Human Genetics, Ohio State University, Columbus, Ohio 43210, USA.
  • Ravichandran K; Molecular and Cellular Oncogenesis Program, The Wistar Institute, 36th and Spruce Sts. Philadelphia, Pennsylvania 19104, USA.
  • Riethman H; Molecular and Cellular Oncogenesis Program, The Wistar Institute, 36th and Spruce Sts. Philadelphia, Pennsylvania 19104, USA.
  • Naber SP; Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.
  • Näär AM; Department of Cell Biology, Harvard Medical School and Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
  • Blasco MA; Telomeres and Telomerase Group, Spanish National Cancer Centre, Madrid E-28029, Spain.
  • Hinds PW; Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.
  • Kuperwasser C; 1] Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA [2] Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, Massachu
Nat Commun ; 6: 7505, 2015 Jun 24.
Article en En | MEDLINE | ID: mdl-26106036
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senescencia Celular / Genes BRCA1 / Glándulas Mamarias Humanas / Inestabilidad Genómica / Células Epiteliales / Haploinsuficiencia / Acortamiento del Telómero Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Senescencia Celular / Genes BRCA1 / Glándulas Mamarias Humanas / Inestabilidad Genómica / Células Epiteliales / Haploinsuficiencia / Acortamiento del Telómero Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido