Your browser doesn't support javascript.
loading
Incidence and Risk Factors for Respiratory Syncytial Virus and Human Metapneumovirus Infections among Children in the Remote Highlands of Peru.
Wu, Andrew; Budge, Philip J; Williams, John; Griffin, Marie R; Edwards, Kathryn M; Johnson, Monika; Zhu, Yuwei; Hartinger, Stella; Verastegui, Hector; Gil, Ana I; Lanata, Claudio F; Grijalva, Carlos G.
Afiliación
  • Wu A; School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Budge PJ; Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, United States of America.
  • Williams J; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Griffin MR; Department of Health Policy, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Edwards KM; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt Vaccine Research Program, Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Johnson M; Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Zhu Y; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Hartinger S; Swiss Tropical and Public Health Institute, Basel, Switzerland; Instituto de Investigación Nutricional, Lima, Peru.
  • Verastegui H; Instituto de Investigación Nutricional, Lima, Peru.
  • Gil AI; Instituto de Investigación Nutricional, Lima, Peru.
  • Lanata CF; Instituto de Investigación Nutricional, Lima, Peru.
  • Grijalva CG; Department of Health Policy, Vanderbilt University, Nashville, Tennessee, United States of America.
PLoS One ; 10(6): e0130233, 2015.
Article en En | MEDLINE | ID: mdl-26107630
ABSTRACT

INTRODUCTION:

The disease burden and risk factors for respiratory syncytial virus (RSV) and human metapneumovirus (MPV) infections among children living in remote, rural areas remain unclear. MATERIALS AND

METHODS:

We conducted a prospective, household-based cohort study of children aged <3 years living in remote rural highland communities in San Marcos, Cajamarca, Peru. Acute respiratory illnesses (ARI), including lower respiratory tract infection (LRTI), were monitored through weekly household visits from March 2009 through September 2011. Nasal swabs collected during ARI/LRTI were tested for RSV, MPV, and other respiratory viruses using real-time RT-PCR. Incidence rates and rate ratios were calculated using mixed effects Poisson regression.

RESULTS:

Among 892 enrolled children, incidence rates of RSV and MPV ARI were 30 and 17 episodes per 100 child-years, respectively. The proportions of RSV and MPV ARI that presented as LRTI were 12.5% and 8.9%, respectively. Clinic visits for ARI and hospitalizations were significantly more frequent (all p values <0.05) among children with RSV (clinic 41% and hospital 5.3%) and MPV ARI (38% and 3.5%) when compared with other viral infections (23% and 0.7%) and infections without virus detected (24% and 0.6%). In multivariable analysis, risk factors for RSV detection included younger age (RR 1.02, 95% CI 1.00-1.03), the presence of a smoker in the house (RR 1.63, 95% CI 1.12-2.38), residing at higher altitudes (RR 1.93, 95% CI 1.25-3.00 for 2nd compared to 1st quartile residents; RR 1.98, 95% CI 1.26-3.13 for 3rd compared to 1st quartile residents). Having an unemployed household head was significantly associated with MPV risk (RR 2.11, 95% CI 1.12-4.01).

CONCLUSION:

In rural high altitude communities in Peru, childhood ARI due to RSV or MPV were common and associated with higher morbidity than ARI due to other viruses or with no viral detections. The risk factors identified in this study may be considered for interventional studies to control infections by these viruses among young children from developing countries.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Virus Sincitial Respiratorio / Infecciones por Paramyxoviridae Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: America do sul / Peru Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Virus Sincitial Respiratorio / Infecciones por Paramyxoviridae Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: America do sul / Peru Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos