Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein.
Indian J Biochem Biophys
; 52(2): 119-24, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-26118122
The role of angiotensin II in regulating Na+/K(+)-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2*-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arteria Pulmonar
/
Angiotensina II
/
ATPasa Intercambiadora de Sodio-Potasio
/
Glutatión
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
Indian J Biochem Biophys
Año:
2015
Tipo del documento:
Article
Pais de publicación:
India