Ethyl chloride: 11-day continuous exposure inhalation toxicity study in B6C3F1 mice.
Fundam Appl Toxicol
; 13(3): 516-22, 1989 Oct.
Article
en En
| MEDLINE
| ID: mdl-2612784
ABSTRACT
Groups of seven B6C3F1 mice per sex were exposed for 23 hr/day to 0, 250, 1250, or 5000 ppm ethyl chloride (EtCl) for 11 consecutive days to evaluate the potential toxicity of EtCl under near-continuous exposure conditions. On the day following the last exposure, a neurobehavioral observation battery was performed, samples were obtained for clinical chemistry and hematology, and necropsies were conducted. Histopathologic examination was subsequently performed. The only observed effects were increased relative liver weights and a slight increase in hepatocellular vacuolation (glycogen or fat) in 5000 ppm-exposed mice. Exposures to EtCl were well tolerated despite the unusually long exposure periods.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cloruro de Etilo
Límite:
Animals
Idioma:
En
Revista:
Fundam Appl Toxicol
Año:
1989
Tipo del documento:
Article