Disruption of Circadian Rhythms and Sleep on Critical Illness and the Impact on Cardiovascular Events.
Curr Pharm Des
; 21(24): 3505-11, 2015.
Article
en En
| MEDLINE
| ID: mdl-26144940
ABSTRACT
The cardiovascular system exhibits significant daily rhythms in physiologic processes (heart rate, blood pressure, cardiac contractility and function), and molecular gene and protein expression. An increasing number of clinical and experimental studies demonstrate the circadian system is an important underlying mechanism that coordinates these rhythmic processes for the health of the cardiovascular system. However, what happens when rhythms are disturbed has been generally clinically unappreciated. Here we describe the profound adverse impact of disturbed circadian rhythms and sleep on the cardiovascular system, including recovery from myocardial infarction in acute care settings, shift work and heart disease, sleep disorders including obstructive sleep apnea, and cardiovascular pathophysiology associated with disturbed nocturnal blood pressure profiles. We also discuss therapeutic applications of circadian rhythms for the cardiovascular system. Cardiovascular disease is a leading cause of death worldwide, and applying circadian biology to cardiology (and indeed medicine in general) provides a new translational approach to benefit patients clinically.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos del Sueño-Vigilia
/
Enfermedades Cardiovasculares
/
Trastornos Cronobiológicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Pharm Des
Asunto de la revista:
FARMACIA
Año:
2015
Tipo del documento:
Article