The AlkB Family of Fe(II)/&#945;-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.

Fedeles, Bogdan I; Singh, Vipender; Delaney, James C; Li, Deyu; Essigmann, John M

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.

Fedeles, Bogdan I; Singh, Vipender; Delaney, James C; Li, Deyu; Essigmann, John M.

Afiliación

Fedeles BI; Departments of Chemistry and Biological Engineering and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Singh V; Departments of Chemistry and Biological Engineering and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Delaney JC; Departments of Chemistry and Biological Engineering and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Li D; Departments of Chemistry and Biological Engineering and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. Electronic address: deyuli@uri.edu.
Essigmann JM; Departments of Chemistry and Biological Engineering and the Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. Electronic address: jessig@mit.edu.

J Biol Chem ; 290(34): 20734-20742, 2015 Aug 21.

Article en En | MEDLINE | ID: mdl-26152727

Asunto(s)

Reparación del ADN; Dioxigenasas/metabolismo; Proteínas de Escherichia coli/metabolismo; Hierro/metabolismo; Ácidos Cetoglutáricos/metabolismo; Oxigenasas de Función Mixta/metabolismo; Homólogo 4 de AlkB Lisina Desmetilasa; Alquilación; Daño del ADN; ADN de Cadena Simple/genética; ADN de Cadena Simple/metabolismo; Dioxigenasas/genética; Escherichia coli/enzimología; Escherichia coli/genética; Proteínas de Escherichia coli/genética; Expresión Génica; Humanos; Isoenzimas/genética; Isoenzimas/metabolismo; Oxigenasas de Función Mixta/genética; Modelos Moleculares; Familia de Multigenes; Oxidación-Reducción; Especificidad por Sustrato

Palabras clave

DNA demethylation; DNA repair; RNA demethylation; RNA repair; alkB; alkylation damage; dioxygenase; direct reversal; metalloprotein; substrate specificity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Escherichia coli / Dioxigenasas / Reparación del ADN / Oxigenasas de Función Mixta / Hierro / Ácidos Cetoglutáricos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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