A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis.
N Engl J Med
; 373(2): 154-62, 2015 Jul 09.
Article
en En
| MEDLINE
| ID: mdl-26154788
ABSTRACT
Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. With the use of a metagenomic approach that incorporated next-generation sequencing and real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contact squirrel and in brain samples from the three patients. Phylogenetic analyses showed that this virus, tentatively named variegated squirrel 1 bornavirus (VSBV-1), forms a lineage separate from that of the known bornavirus species. (Funded by the Federal Ministry of Food and Agriculture [Germany] and others.).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sciuridae
/
Encéfalo
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Infecciones por Mononegavirales
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Encefalitis Viral
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Bornaviridae
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Animals
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
N Engl J Med
Año:
2015
Tipo del documento:
Article