Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-&#954;B signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells.

Ku, Jin Mo; Kim, Soon Re; Hong, Se Hyang; Choi, Han-Seok; Seo, Hye Sook; Shin, Yong Cheol; Ko, Seong-Gyu

Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells.

Ku, Jin Mo; Kim, Soon Re; Hong, Se Hyang; Choi, Han-Seok; Seo, Hye Sook; Shin, Yong Cheol; Ko, Seong-Gyu.

Afiliación

Ku JM; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Kim SR; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Hong SH; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Choi HS; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Seo HS; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Shin YC; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea.
Ko SG; Laboratory of Clinical Biology and Pharmacogenomics, Department of Preventive Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea. epiko@khu.ac.kr.

Mol Cell Biochem ; 409(1-2): 33-43, 2015 Nov.

Article en En | MEDLINE | ID: mdl-26169986

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias de la Mama/tratamiento farmacológico; Doxorrubicina/farmacología; Puntos de Control de la Fase G2 del Ciclo Celular/efectos de los fármacos; FN-kappa B/antagonistas & inhibidores; Factor de Transcripción STAT3/antagonistas & inhibidores; Triterpenos/farmacología; Neoplasias de la Mama/patología; Caspasas/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Resistencia a Múltiples Medicamentos; Resistencia a Antineoplásicos; Femenino; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Proteínas I-kappa B/metabolismo; Células MCF-7; Inhibidor NF-kappaB alfa; FN-kappa B/metabolismo; Factor de Transcripción STAT3/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Breast cancer; Cucurbitacin D; Doxorubicin; MCF7 cell; MCF7/ADR cell; Multidrug resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Neoplasias de la Mama / Doxorrubicina / FN-kappa B / Apoptosis / Factor de Transcripción STAT3 / Puntos de Control de la Fase G2 del Ciclo Celular Límite: Female / Humans Idioma: En Revista: Mol Cell Biochem Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos

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