Dyskinesia detection and monitoring by a single sensor in patients with Parkinson's disease.
Mov Disord
; 30(9): 1267-71, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26179817
ABSTRACT
OBJECTIVE:
In current clinical practice, assessment of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD) is based on semiquantitative scales or patients' diaries. We aimed to assess the feasibility, clinical validity, and usability of a waist-worn inertial sensor for discriminating between LIDs and physiological sway in both supervised and unsupervised settings.METHODS:
Forty-six PD patients on L-dopa therapy, 18 de novo PD patients, and 18 healthy controls were enrolled. Patients underwent clinical assessment of motor signs and dyskinesias and kinetic-dynamic L-dopa monitoring, tracked by serial measurements of plasma drug concentrations and motor and postural tests.RESULTS:
A subset of features was selected, which showed excellent reliability. Sensitivity and specificity of the selected features for dyskinesia recognition were assessed in both supervised and unsupervised settings with an accuracy of 95% and 86%, respectively.CONCLUSIONS:
Our preliminary findings suggest that it is feasible to design a reliable sensor-based application for dyskinesia monitoring at home.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Postura
/
Detección de Señal Psicológica
/
Discinesia Inducida por Medicamentos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mov Disord
Asunto de la revista:
NEUROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Italia