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Possible prevention of dialysis-requiring congestive heart failure by angiotensin-II receptor blockers in non-dialysis Japanese patients with Stage 5 chronic kidney disease.
Ikeda, Masato; Nakao, Masatsugu; Hirano, Keita; Yokoyama, Keitaro; Yokoo, Takashi; Joki, Nobuhiko; Ando, Ryoichi; Shinoda, Toshio; Inaguma, Daijo; Yamaka, Toshihiko; Komatsu, Yasuhiro; Koiwa, Fumihiko; Sakaguchi, Toshifumi; Negi, Shigeo; Shigematsu, Takashi.
Afiliación
  • Ikeda M; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Katsushika medical center, Tokyo, Japan aoto-jinnai@jikei.ac.jp.
  • Nakao M; Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Katsushika medical center, Tokyo, Japan.
  • Hirano K; Department of Nephrology, Asikaga Red Cross Hospital, Gunma, Japan.
  • Yokoyama K; Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
  • Yokoo T; Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan.
  • Joki N; Division of Nephrology, Toho University, Ohashi Medical Center, Tokyo, Japan.
  • Ando R; Department of Nephrology, Musashino Red Cross Hospital, Tokyo, Japan.
  • Shinoda T; Dialysis Center, Kawakita General Hospital, Tokyo, Japan.
  • Inaguma D; Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
  • Yamaka T; Department of Clinical Engineering, Tokyo Yamate Medical Center, Tokyo, Japan.
  • Komatsu Y; Department of Nephrology, Division of Internal Medicine, Saint Luke's International Hospital, Tokyo, Japan.
  • Koiwa F; Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
  • Sakaguchi T; Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
  • Negi S; Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
  • Shigematsu T; Division of Nephrology, Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
J Renin Angiotensin Aldosterone Syst ; 16(4): 1175-84, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26195266
BACKGROUND: Preventive medications for dialysis-requiring congestive heart failure (CHF) in non-dialysis Japanese patients with Stage 5 chronic kidney disease (CKD) are unknown. Our aim was to explore which CKD medication was associated with a reduced prevalence of dialysis-requiring CHF in non-dialysis Japanese patients with Stage 5 CKD. METHODS: The present multicenter, retrospective, cross-sectional study examined the association between CKD medications and the prevalence of dialysis-requiring CHF in non-dialysis Japanese patients with Stage 5 CKD. RESULTS: There were 1536 Japanese Stage 5 CKD patients who satisfied our inclusion criteria. We had 309 (20.1%) patients whom had developed dialysis-requiring CHF and 940 patients (60.8%) whom had been using angiotensin-II receptor blockers (ARBs) before initiating dialysis. In our multivariate analysis, only ARB use was significantly associated with a lower risk of CHF (Odds ratio (OR): 0.680, 95% confidence interval (CI): 0.516-0.897; p = 0.0064), of the CKD treatments examined in this study. CONCLUSIONS: We found that ARB use during the pre-dialysis period is associated with a lower prevalence of CHF in the non-dialysis Japanese patients with Stage 5 CKD, suggesting a possible prevention of dialysis-requiring CHF by ARBs, in non-dialysis Japanese patients with Stage 5 CKD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Pueblo Asiatico / Antagonistas de Receptores de Angiotensina / Insuficiencia Cardíaca / Fallo Renal Crónico Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Renin Angiotensin Aldosterone Syst Asunto de la revista: FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Pueblo Asiatico / Antagonistas de Receptores de Angiotensina / Insuficiencia Cardíaca / Fallo Renal Crónico Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Renin Angiotensin Aldosterone Syst Asunto de la revista: FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido